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2.4 · 第 50

第50期 The courage to live with radical uncertainty (5)

第10篇 · 第5期

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And then, just as I ____________________________________ and feeling like I might not necessarily fail out of medical school, I ____________ even more devastating news. I learned that I had a mutation in a gene called TP53, or p53 for short. Known as the guardian of the genome, a mutation -- p53 is responsible for supervising the ____________ our DNA. A mutation in this gene means ____________________________________.It means that normal cells become cancerous ___________________________________________________________, my medical history made a terrible kind of sense. I had had a __________________ cancer -- rhabdomyosarcoma -- at age seven. It ____________ when I was a teenager. And this was all before p53 had been discovered in the lab. Then I'd had young adult breast and lung cancers.With the knowledge of this mutation, it seemed that _________________________________________that I could expect in my future. And yet, I decided to become a radiation oncologist. I hoped to graduate from residency in just a few months, move to a new city and start my first real job as a doctor and researcher, because of grit, because of ____________, because of ____________, because of my medical teams and my family and my teachers, because genetic diagnoses should give us the knowledge _________________ _____________.

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And then, just as I was getting comfortable and feeling like I might not necessarily fail out of medical school, I received even more devastating news.

正当我越来越适应这样的生活后,开始觉得我不见得会被医学院退学的时候,我却收到了更加令我倍受打击的消息。

be getting 有状态变化的含义,可以意译为越来越...或者逐渐... comfortable除了我们熟悉的“舒服的”,还可以表示不难受的,适应的

I learned that I had a mutation in a gene called TP53, or p53 for short. Known as the guardian of the genome, a mutation -- p53 is responsible for supervising the repair of our DNA. A mutation in this gene means errors go uncorrected.

我得知我体内有一个 TP53,或简称 p53 的基因发生了突变。这个我们所谓的基因守护者,发生了突变——p53 负责监督基因的修复。当这个基因发生突变,就表示错误将不会被修正。

devastating [ˈdevəsteɪtɪŋ] adj. 毁灭性的,极具破坏力的; v. 毁灭,使极度震惊,devastate 的现在分词形式 genome [ˈdʒiːnoʊm] n. 基因组,染色体组 guardian [ˈɡɑːrdiən] n. 监护人;守卫者,保护者;adj. 守护的 mutation [mjuːˈteɪʃ(ə)n] n. (动物或植物的)突变,变异;改变;语流音变,变音 supervise [ˈsuːpərvaɪz] v. 指导(某人)的工作;监督(任务,计划,活动)

It means that normal cells become cancerousat a much higher rate. All of a sudden, with this knowledge, my medical history made a terrible kind of sense. I had had a childhood cancer -rhabdomyosarcoma -at age seven. It recurred when I was a teenager. And this was all before p53 had been discovered in the lab. Then I'd had young adult breast and lung cancers.

这就意味着正常细胞变成癌细胞的可能性将会大大提高。突然间收到这个消息,再加上我先前的病史,让我有种非常糟的感觉。我小时候就得过癌症——横纹肌肉瘤——当年的我只有七岁。在青春期时它又复发了。这些都是在p53被查出来之前的事。接着我就在年轻的时候又患上了乳腺癌和肺癌。

cancerous [ˈkænsərəs] adj. 癌的;生癌的;像癌的 recur [rɪˈkɜːr] vi.复发,重现;再发生;反复出现

With the knowledge of this mutation, it seemed that there was likely no end to the number of cancers that I could expect in my future. And yet, I decided to become a radiation oncologist.

当得知发生了基因突变后,我就有种预感,自己在未来将会无止境地罹患癌症。即便如此,我依然决定成为一位放射科肿瘤医生。

radiation [ˌreɪdiˈeɪʃn] n.辐射;放射线 oncologist 肿瘤学家

I hoped to graduate from residency in just a few months, move to a new city and start my first real job as a doctor and researcher, because of grit, because of privilege, because of therapy, because of my medical teams and my family and my teachers, because genetic diagnoses should give us the knowledge to move forward.

我希望我能在几个月内完成实习,搬到一个新的城市,以医生兼研究者的身份开始我的第一份工作——因为毅力,因为殊荣,因为治疗,因为我的医疗团队、我的家人、我的老师,因为基因诊断应该带给我们向前迈进的知识。

residency [ˈrezɪdənsi] n. 住处;住院医生实习期 grit [ɡrɪt] n. 沙砾,沙粒;勇气,毅力;粗砂岩; v. (为防滑)在(路面上)撒沙砾;咬紧牙关 privilege [ˈprɪvəlɪdʒ] n. 特权 荣幸,殊荣 权势; v.特别优待;免除(某人) therapy [ˈθerəpi] n. 治疗,疗法;心理治疗;(对身心健康)有裨益的活动 genetic [dʒəˈnetɪk] adj. 基因的,遗传学的 diagnose [ˌdaɪəɡˈnoʊs] v. 诊断(病症);找出原因